Got this in the mail and wanted to share. Motel 6 is a favorite of doggie people. When you pull into a Motel 6 late at night, it’s nice to know your dogs are welcome. It’s no fun cruising around, late at night, road tired, trying to find accommodations for both you and your dog/s! I love that they’re now the official lodging provider to the American Kennel Club. There’s never a Pet Fee and now the 1 pet per room restriction has been lifted. This would often be lifted if there was a dog show in the area, but now it’s lifted always!
From the August 1, 2001 edition of the Canyon Courier…
Evergreen vet to be featured on ‘Animal Planet’
Kathy shared this with me several years ago, along with this note “Mary was well into her 70’s with this pic…
Apparently from a series titled The Way We Really Were, the lead-in: A controversial plan devised by a New Englander and a Navajo resulted in the preservation of history.
The article printed in House and Garden some years ago began “A beautifully restored Newport farm is the site for a bold program to protect and preserve rare and endangered breeds of farm animals. ”
The article is about Swiss Village Farm. From the website, “Rare breeds of livestock carry valuable and irreplaceable traits such as innate disease resistance, heat tolerance, parasite resistance and mothering ability qualities which may be needed at some time in the future. It is conceivable that a current popular breed may become jeopardized due to a shift in the factors that let to its predominant role, such as industry demand or infectious disease.”
is now online. It will be 15 years in June since Gabrielle was diagnosed with Renal Dysplasia, beginning our quest for knowledge and our dedication for a useful tool for breeders.
Peer-reviewed and published online at the Public Library of Science, I am very proud to be one of the co-authors on this paper.
1 DOGenes Inc., Peterborough, Ontario, Canada, 2 Department of Clinical Sciences, Tufts Cummings School of Veterinary Medicine, North Grafton, Massachusetts, United States of America, 3 American Lhasa Apso Club, Conifer, Colorado, United States of America
Renal dysplasia (RD) in dogs is a complex disease with a highly variable phenotype and mode of inheritance that does not follow a simple Mendelian pattern. Cox-2 (Cyclooxgenase-2) deficient mice have renal abnormalities and a pathology that has striking similarities to RD in dogs suggesting to us that mutations in the Cox-2 gene could be the cause of RD in dogs. Our data supports this hypothesis. Sequencing of the canine Cox-2 gene was done from clinically affected and normal dogs. Although no changes were detected in the Cox-2 coding region, small insertions and deletions of GC boxes just upstream of the ATG translation start site were found. These sequences are putative SP1 transcription factor binding sites that may represent important cis-acting DNA regulatory elements that govern the expression of Cox-2. A pedigree study of a family of Lhasa apsos revealed an important statistical correlation of these mutant alleles with the disease. We examined an additional 22 clinical cases from various breeds. Regardless of the breed or severity of disease, all of these had one or two copies of the Cox-2 allelic variants. We suggest that the unusual inheritance pattern of RD is due to these alleles, either by changing the pattern of expression of Cox-2 or making Cox-2 levels susceptible to influences of other genes or environmental factors that play an unknown but important role in the development of RD in dogs.
We wish to thank J. Kassis for careful review of the manuscript. The authors wish to dedicate this work to the late Dr. John B. Armstrong, canine geneticist and poodle fancier. He gave much of his time to educate the breeders and owners of purebred dogs about the importance of genetic diversity. His careful analysis of Poodle and Lhasa apso pedigrees with respect to RD were invaluable in the inception of this research. The authors pay tribute to Chiata, a Lhasa Apso who opened the door to discovery. We are grateful to the many dog owners who submitted DNA samples for this study.