Renal Dysplasia

Fleetfire Timbers Macchiata
by Debby RothmanJuly 5, 1996 – November 15, 2004
(wedge biopsy 40% fetal glomeruli)

“Chiata … head high, little one, nose to the wind … the ancestral home beckons.
Chiata has already made a difference, both in life and in death. She was part of the beginning of your long journey as it was redefined by RD. In death, she exemplifies the responsibility of a breeder to ensure the health of future generations … and that things are not always what they seem. Throw on the mantle of her memory, for it will surely warm you as you continue the path set before you.

Written by Vickie Kuhlmann
after Chiata’s death

Chiata as a puppy

Renal Dysplasia (RD) is a hereditary developmental problem pertaining to the kidneys. Canines are born with immature kidneys. By the time the puppy is 8 weeks old, the transition to mature kidneys should be complete. Dogs with RD never complete this transition. A number of other breeds share this problem with Lhasa Apsos.

Debby is co-author on a peer-reviewed paper, published February 2011 at the Public Library of Science, titled Novel Allelic Variants in the Canine Cyclooxgenase-2 (Cox-2) Promoter Are Associated with Renal Dysplasia in Dogs.
The following articles are great resources for learning more about Renal Dysplasia, including Debby’s award-winning series. Breaking The Silence: An Odyssey in Renal Dysplasia. Note! Some of the information – particularly about VetGen – is outdated. The most recent research is available in the above paper.


A Pathway? Or a Superhighway?
A Study of Renal Dysplasia
All Dogs Are Carriers
An Editorial
Bradykinin B2 null mice are prone to renal dysplasia: gene-environment interactions in kidney development
Breaking The Silence:
An Odyssey in Renal Dysplasia
Part 1
Part 2
Part 3
Clinicopathologic manifestations of progressive renal disease in Lhasa Apso and Shih Tzu dogs
Congential Kidney Diseases
DNA Swab Sampling Instructions
Enzymological characterization of a putative canine analogue of primary hyperoxaluria type 1
Familial Kidney Disease
Feeding A Dog With Kidney Disease
General Information on Renal Dysplasia
Hereditary Kidney Disease in Dogs
How to Collect DNA with Cotton Swabs
Important Health Updates
Julie’s Introduction to our RD talk
Juvenile Renal Disease in Standard Poodles
Leslie’s Excellent Post
Lhasa Apso Kidney Research – 1975
Microscopic Features of Canine Renal Dysplasia
Novel Allelic Variants in the Canine Cyclooxgenase-2 (Cox-2) Promoter Are Associated with Renal Dysplasia in Dogs
Oxalate Nephropathy in a Tibetan Spaniel Litter
Pathology of Urinary System
Progressive nephropathy due to renal dysplasia in shih tzu dogs in Sweden
Renal Dysplasia in Shih Tzu Dogs
Renal Dysplasia: New Approaches to an Old Problem
Renal Dysplasia Tables
Shattering The Myths
Test Results
The Reporter Interviews Carl A. Osborne, DVM
The Stillman Letter
This Miserable Thing
Ultrasonographic Findings of Renal Dysplasia in Cocker Spaniels Eight Cases
What is Renal Dysplasia?


Timbers’ Command Performance
Born October 27, 1991
Died February 13, 1997

For discussion on Renal Dysplasia go home, click on Renal Dysplasia in the Category Cloud, along with doing a search on Renal Dysplasia.