Renal Dysplasia

Chiata - Fleetfire Timbers' Macchiata
Fleetfire Timbers Macchiata
July 5, 1996 – November 15, 2004
(wedge biopsy 40% fetal glomeruli)

“Chiata … head high, little one, nose to the wind … the ancestral home beckons.
Chiata has already made a difference, both in life and in death. She was part of the beginning of your long journey as it was redefined by RD. In death, she exemplifies the responsibility of a breeder to ensure the health of future generations … and that things are not always what they seem. Throw on the mantle of her memory, for it will surely warm you as you continue the path set before you.

Written by Vickie Kuhlmann
after Chiata’s death

Chiata - Fleetfire Timbers' Macchiata
Chiata as a puppy

Renal Dysplasia (RD) is a hereditary developmental problem pertaining to the kidneys. Canines are born with immature kidneys. By the time the puppy is 8 weeks old, the transition to mature kidneys should be complete. Dogs with RD never complete this transition. A number of other breeds share this problem with Lhasa Apsos.

Debby is co-author on a peer-reviewed paper, published February 2011 at the Public Library of Science, titled Novel Allelic Variants in the Canine Cyclooxgenase-2 (Cox-2) Promoter Are Associated with Renal Dysplasia in Dogs.
The following articles are great resources for learning more about Renal Dysplasia, including Debby’s award-winning series. Breaking The Silence: An Odyssey in Renal Dysplasia. Note! Some of the information – particularly about VetGen – is outdated. The most recent research is available in the above paper.

A Pathway? Or a Superhighway? by Debby Rothman

A Study of Renal Dysplasia by Dr. Catherine Marley

All Dogs Are Carriers  (of multiple mutations) by Mary H. Whiteley, Ph.D

An Unpublished Editorial by Debby Rothman

Bradykinin B2 null mice are prone to renal dysplasia: gene-environment interactions
in kidney development
El-Dahr SS1Harrison-Bernard LMDipp SYosipiv IVMeleg-Smith S

Breaking The Silence Part 1 by Debby Rothman

Breaking The Silence Part 2 by Debby Rothman

Breaking The Silence Part 3 by Debby Rothman

Clinicopathologic manifestations of progressive renal disease
by Timothy D. O’Brian DVM, Carl A. Osbourne DVM PhD,
Barry L. Yano DVM PhD, Donald M. Barnes DVM PhD

Congenital Renal Diseases By George E. Lees. DMV, MS

Current Research on Hereditary Renal Dysplasia by Dr. Catherine Marley

DNA swab sampling instructions

Dominant with incomplete penetrance Definition by Dr. Mary Whiteley

Enzymological characterization of a putative canine analogue
of primary hyperoxaluria type 1
by Christopher J. Danpure, Patricia R. Jennings, Johan H. Jansen

Evergreen vet to be featured on Animal Planet Canyon Courier

Familial Kidney Disease by Dr. Catherine Marley

Feeding a Dog with Kidney Disease by Caroline Coile, Ph.D.

General Information on Renal Dysplasia by Mary H. Whiteley, Ph.D.

Hereditary Kidney Disease in Dogs by Catherine A Picut VMD, Robert M. Lewis DVM

Important Health Updates by Cassandra de la Rosa

Intro by Julie Timbers to our RD talk

Leslie Baumann’s Post Regarding the RD Tes

Lhasa Apso Kidney Research_1975 by D. R. Finco

Microscopic Features of Canine Renal Dysplasia by CA Picut RMLewis

Novel Allelic Variants in the Canine Cyclooxgenase-2 (Cox-2) Promoter
Are Associated with Renal Dysplasia in Dogs

Pathology of Urinary System

Progressive nephropathy due to renal dysplasia
by A. Hoppe, L Swenson, L Jonnson, A. Hedhammer

Renal Dysplasia DNA Testing by Dr. Mary Whitely

Renal Dysplasia in Shih Tzu Dogs by Kenneth C. Bovee, DVM, M Med Sc

Renal Dysplasia: New Approaches to an Old Problem by Matsell DG

Reporter Interviews Carl A. Osborne, DVM

RD Tables

Shattering The Myths by Debby Rothman

The Common Thread by Debby Rothman

The Stillman Letter written by Marie Stillman circa early 60s

This Miserable Thing By Cassandra de la Rosa

Ultrasonographic Findings of Renal Dysplasia in Cocker Spaniels Eight Cases
Felkai C1Vörös KVrabély TVetési FKarsai FPapp L.

What is Renal Dysplasia? compiled by Dr. Catherine Marley

Whew! Your DNA Isn’t Your Destiny by Brandon Keim