Fleetfire Timbers Macchiata
July 5, 1996 – November 15, 2004
(wedge biopsy 40% fetal glomeruli)
“Chiata … head high, little one, nose to the wind … the ancestral home beckons.
Chiata has already made a difference, both in life and in death. She was part of the beginning of your long journey as it was redefined by RD. In death, she exemplifies the responsibility of a breeder to ensure the health of future generations … and that things are not always what they seem. Throw on the mantle of her memory, for it will surely warm you as you continue the path set before you.”
Written by Vickie Kuhlmann
after Chiata’s death
Chiata as a puppy
Renal Dysplasia (RD) is a hereditary developmental problem pertaining to the kidneys. Canines are born with immature kidneys. By the time the puppy is 8 weeks old, the transition to mature kidneys should be complete. Dogs with RD never complete this transition. A number of other breeds share this problem with Lhasa Apsos.
Debby is co-author on a peer-reviewed paper, published February 2011 at the Public Library of Science, titled Novel Allelic Variants in the Canine Cyclooxgenase-2 (Cox-2) Promoter Are Associated with Renal Dysplasia in Dogs.
The following articles are great resources for learning more about Renal Dysplasia, including Debby’s award-winning series. Breaking The Silence: An Odyssey in Renal Dysplasia. Note! Some of the information – particularly about VetGen – is outdated. The most recent research is available in the above paper.
A Pathway? Or a Superhighway? by Debby Rothman
A Study of Renal Dysplasia by Dr. Catherine Marley
All Dogs Are Carriers (of multiple mutations) by Mary H. Whiteley, Ph.D
An Unpublished Editorial by Debby Rothman
Bradykinin B2 null mice are prone to renal dysplasia: gene-environment interactions
in kidney development
by El-Dahr SS1, Harrison-Bernard LM, Dipp S, Yosipiv IV, Meleg-Smith S
Breaking The Silence Part 1 by Debby Rothman
Breaking The Silence Part 2 by Debby Rothman
Breaking The Silence Part 3 by Debby Rothman
Clinicopathologic manifestations of progressive renal disease
by Timothy D. O’Brian DVM, Carl A. Osbourne DVM PhD,
Barry L. Yano DVM PhD, Donald M. Barnes DVM PhD
Congenital Renal Diseases By George E. Lees. DMV, MS
Current Research on Hereditary Renal Dysplasia by Dr. Catherine Marley
DNA swab sampling instructions
Dominant with incomplete penetrance Definition by Dr. Mary Whiteley
Enzymological characterization of a putative canine analogue
of primary hyperoxaluria type 1
by Christopher J. Danpure, Patricia R. Jennings, Johan H. Jansen
Evergreen vet to be featured on Animal Planet Canyon Courier
Familial Kidney Disease by Dr. Catherine Marley
Feeding a Dog with Kidney Disease by Caroline Coile, Ph.D.
General Information on Renal Dysplasia by Mary H. Whiteley, Ph.D.
Hereditary Kidney Disease in Dogs by Catherine A Picut VMD, Robert M. Lewis DVM
Important Health Updates by Cassandra de la Rosa
Intro by Julie Timbers to our RD talk
Leslie Baumann’s Post Regarding the RD Tes
Lhasa Apso Kidney Research_1975 by D. R. Finco
Microscopic Features of Canine Renal Dysplasia by CA Picut RM, Lewis
Novel Allelic Variants in the Canine Cyclooxgenase-2 (Cox-2) Promoter
Are Associated with Renal Dysplasia in Dogs
Pathology of Urinary System
Progressive nephropathy due to renal dysplasia
by A. Hoppe, L Swenson, L Jonnson, A. Hedhammer
Renal Dysplasia DNA Testing by Dr. Mary Whitely
Renal Dysplasia in Shih Tzu Dogs by Kenneth C. Bovee, DVM, M Med Sc
Renal Dysplasia: New Approaches to an Old Problem by Matsell DG
Reporter Interviews Carl A. Osborne, DVM
Shattering The Myths by Debby Rothman
The Common Thread by Debby Rothman
The Stillman Letter written by Marie Stillman circa early 60s
This Miserable Thing By Cassandra de la Rosa
Ultrasonographic Findings of Renal Dysplasia in Cocker Spaniels Eight Cases
by Felkai C1, Vörös K, Vrabély T, Vetési F, Karsai F, Papp L.
What is Renal Dysplasia? compiled by Dr. Catherine Marley
Whew! Your DNA Isn’t Your Destiny by Brandon Keim